ACETIC ACID, [1-14C]

Base Information

• Chemical Name: ACETIC ACID, [1-14C]
• CAS No.: 2845-03-6
• Molecular Formula: C2H4 O2
• Molecular Weight: 62.0416
• Mol file: 2845-03-6.mol

Synonyms:Acetic-1-C14acid (5CI); Acetic-1-14C1 acid; [1-14C]Acetate

Chemical Property of ACETIC ACID, [1-14C]

Chemical Property:

• Flash Point: 40 °C
• PSA: 37.30000
• LogP: 0.09090
• Storage Temp.: 2-8°C

Purity/Quality:

ACETIC ACID-[1-14C] 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,R
• Statements: 10-35
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETIC ACID, [1-14C]

There total 9 articles about ACETIC ACID, [1-14C] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl magnesium iodide (917-64-6) + [14C]carbon dioxide (51-90-1) → 14C-acetic acid (2845-03-6)

Guidance literature:

In diethyl ether; reaction at -20°C, hydrolysis with ice water;;

DOI:10.1515/bchm2.1955.301.1-2.46

Reference yield: 97.0%

methyl magnesium iodide (917-64-6) + carbon dioxide (124-38-9,18923-20-1) + barium [14-C]carbonate (1882-53-7,51118-03-7,58454-84-5) → 14C-acetic acid (2845-03-6)

Guidance literature:

In diethyl ether; reaction at low temp.;;

Reference yield:

[1-14C]caproic acid (55322-50-4) → 14C-acetic acid (2845-03-6) + [14C]-Butyric acid (41130-44-3) + [1-14C]propionic acid (4561-18-6) + valeric acid (109-52-4)

Guidance literature:

With 2-Methylcyclohexanol; ozone; at 80 ℃; for 3h;

DOI:10.1023/B:RJAC.0000008316.31725.9f

upstream raw materials:

methyl magnesium iodide

[14C]carbon dioxide

methylmagnesium bromide

[1-14C]caproic acid

Downstream raw materials:

24-methylenecycloartanol

cycloartanol

obtusifoliol

24-methylenecycloartan-3β-ol

Refernces

INVESTIGATIONS ON THE BIOSYNTHESIS OF FLEXIRUBIN - THE ORIGIN OF BENZENE RING B AND ITS SUBSTITUENTS

10.1016/S0040-4020(01)97645-8

The research presents an in-depth investigation into the biosynthesis of flexirubin, a pigment produced by the gliding bacterium Flexibacter elegans. The study aimed to trace the origin of the benzene ring B and its substituents in flexirubin, using "C- and "C-labeled acetate and butyrate. The conclusions drawn from the experiments were that all carbon atoms of ring B and its alkyl substituents are derived from acetate, with 3-dodecylorsellinic and orsellinic acid identified as intermediates in the biosynthesis. The research also established that the carboxyl group of orsellinic acid is lost before the ester linkage with the w-phenyl-polyene carboxylic acid or its precursor is formed. Chemicals used in the process included various isotopically labeled precursors such as [1-14C]acetate, [2-14C]acetate, [1-14C]butyrate, and [1-13C]propionate, as well as reagents for chemical degradation and analysis like lithium aluminum hydride, ozone, and p-bromo-phenacyl bromide. The study employed techniques such as mass spectrometry, NMR spectroscopy, and high-performance liquid chromatography to analyze the distribution of radioactivity and isotopic enrichment in the synthesized flexirubin and its degradation products.