2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

Base Information

Chemical Name:2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide
CAS No.:1192313-61-3
Molecular Formula:C₂₁H₂₂F₄N₄O₄
Molecular Weight:470.424
Hs Code.:

Synonyms:2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

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Chemical Property of 2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

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Technology Process of 2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

There total 4 articles about 2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₄F₄N₄O₅

: C₂₃H₂₄F₄N₄O₅

: 1192313-60-2
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

: 1192313-61-3
2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

Guidance literature:: C₂₃H₂₄F₄N₄O₅; C₂₃H₂₄F₄N₄O₅; With lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With water; In dichloromethane;

Reference yield:

: 2895-21-8
2-chloro-N-isopropylacetamide

: 1192313-61-3
2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere of N₂

1.2: 0 - 60 °C

2.1: lithium hydroxide / tetrahydrofuran / 20 °C

With lithium hydride; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1192313-59-9
3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

: 1192313-61-3
2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere of N₂

1.2: 0 - 60 °C

2.1: lithium hydroxide / tetrahydrofuran / 20 °C

With lithium hydride; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;