3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

Base Information

• Chemical Name: 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate
• CAS No.: 1192313-59-9
• Molecular Formula: C₁₈H₁₅F₄N₃O₄
• Molecular Weight: 413.328

Synonyms:3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

Chemical Property of 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

Chemical Property:

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Technology Process of 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate

There total 2 articles about 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-1-H-pyrazole-5-carboxylate (1192313-58-8) + ammonium acetate (631-61-8,92206-38-7) → 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate (1192313-59-9)

Guidance literature:

With acetic acid; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.07.037

Reference yield:

→ 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate (1192313-59-9)

Guidance literature:

Reference yield:

N-tert-butylchloroacetamide (15678-99-6) + 3-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazin-2-yl}oxy)propyl acetate (1192313-59-9) → C24H26F4N4O5 (1192313-63-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃;

upstream raw materials:

ethyl 3-[(3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)oxy]-1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-1-H-pyrazole-5-carboxylate

ammonium acetate

Downstream raw materials:

C₂₄H₂₆F₄N₄O₅

2-({6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]pyrazolo[1,5-a]pyrazin-4-yl}oxy)-N-(1-methylethyl)acetamide

N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-2-[(3-hydroxypropyl)oxy]-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide

N-(1,1-dimethylethyl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide hydrochloride salt

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