(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

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Chemical Name:(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine
CAS No.:1198009-55-0
Molecular Formula:C₂₈H₃₉N₅
Molecular Weight:445.651
Hs Code.:

Synonyms:(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

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Chemical Property of (E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

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Technology Process of (E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

There total 5 articles about (E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 4318-42-7
1-(1-methylethyl)piperazine

: 1197880-15-1
(E)-3-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol

: 1198009-55-0
(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2017.06.050

Reference yield:

: 22934-23-2
2-amino-4,6-dimethyl-3-nitropyridine

: 1198009-55-0
(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; palladium 10% on activated carbon / ethanol / 4 h / 20 °C / 760.05 Torr

2.1: polyphosphoric acid / 2 h / 190 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: dicyclohexylmethylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 130 °C / Inert atmosphere; Microwave irradiation

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

6.1: (cyanomethyl)trimethyl-phosphonium iodide; N-ethyl-N,N-diisopropylamine / 2 h / 120 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; palladium 10% on activated carbon; dicyclohexylmethylamine; hydrogen; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: |Heck Reaction;
DOI:10.1016/j.bmc.2017.06.050

Reference yield:

: 1197880-16-2
3-(4-bromobenzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

: 1198009-55-0
(E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylmethylamine; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.08 h / 130 °C / Inert atmosphere; Microwave irradiation

2: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C / Inert atmosphere

3: (cyanomethyl)trimethyl-phosphonium iodide; N-ethyl-N,N-diisopropylamine / 2 h / 120 °C / Inert atmosphere

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; dicyclohexylmethylamine; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; (cyanomethyl)trimethyl-phosphonium iodide; In 1,4-dioxane; dichloromethane; toluene; 1: |Heck Reaction;
DOI:10.1016/j.bmc.2017.06.050