cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

Base Information

Chemical Name:cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate
CAS No.:1257085-89-4
Molecular Formula:C₃₆H₃₅F₂NO₆
Molecular Weight:615.674
Hs Code.:

Synonyms:cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

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Chemical Property of cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

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Technology Process of cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

There total 2 articles about cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1257086-79-5
(6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid

: 590-17-0
cyanomethyl bromide

: 1257085-89-4
cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 90h;

Reference yield:

: 22746-83-4
4-benzylbenzoyl chloride

: 1234557-20-0
(6α,11β,17α)-6,9-difluoro-11,17-dihydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid

: 1257085-89-4
cyanomethyl (6α,11β,17α)-17-[(4-benzylbenzoyl)oxy]-6,9-difluoro-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 90 h / 0 - 20 °C

With sodium hydrogencarbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;