Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

Base Information

Chemical Name:Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide
CAS No.:1027076-61-4
Molecular Formula:C₂₀H₂₈Cl₂N₄O₄
Molecular Weight:459.373
Hs Code.:

Synonyms:Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

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Chemical Property of Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

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Technology Process of Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

There total 3 articles about Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129739-09-9
4-methyl-2S-[(morpholine-4-carbonyl)amino]pentanoic acid

: 1027076-61-4
Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

Guidance literature:: 4-methyl-2S-[(morpholine-4-carbonyl)amino]pentanoic acid; L-3,4-dichlorophenylalaninamide-Sieber Resin; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 22 ℃; for 16h;

With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 0.5h; Further stages.;
DOI:10.1021/jm020209i

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 1027076-61-4
Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-diisopropylethylamine / dimethylformamide / 16 h

2.1: Pd(OH)2 / ethanol; cyclohexane / 0.75 h / Heating

3.1: EDC; HOBt / dimethylformamide / 16 h / 22 °C

3.2: TFA / CH₂Cl₂ / 0.5 h / 22 °C

With palladium dihydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In ethanol; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm020209i

Reference yield:

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

: 1027076-61-4
Morpholine-4-carboxylic acid {(S)-1-[(S)-1-carbamoyl-2-(3,4-dichloro-phenyl)-ethylcarbamoyl]-3-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-diisopropylethylamine / dimethylformamide / 16 h

2.1: Pd(OH)2 / ethanol; cyclohexane / 0.75 h / Heating

3.1: EDC; HOBt / dimethylformamide / 16 h / 22 °C

3.2: TFA / CH₂Cl₂ / 0.5 h / 22 °C

With palladium dihydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In ethanol; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm020209i