6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol

Base Information

Chemical Name:6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol
CAS No.:550997-74-5
Molecular Formula:C₁₆H₁₁ClO₂
Molecular Weight:270.715
Hs Code.:
DSSTox Substance ID:DTXSID201263156
Pharos Ligand ID:NC5RQJLS541K
ChEMBL ID:CHEMBL365999

Synonyms:CHEMBL365999;6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol;D0K6TE;SCHEMBL4012132;UVRXGDFVCKYIGU-UHFFFAOYSA-N;DTXSID201263156;BDBM50168370;PD182712;6-(3-chloro-4-hydroxyphenyl)-2-naphthol;6-(3-Chloro-4-hydroxyphenyl)-2-naphthalenol;550997-74-5

Suppliers and Price of 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:270.0447573
Heavy Atom Count:19
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=C(C=CC(=C2)O)C=C1C3=CC(=C(C=C3)O)Cl

Technology Process of 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol

There total 3 articles about 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 550998-15-7
2-chloro-4-(6-methoxy-2-naphthyl)phenol

: 550997-74-5
6-(3-chloro-4-hydroxyphenyl)-2-naphthol

Guidance literature:: With C₆H₅N*HCl; at 190 ℃; for 2h;
DOI:10.1021/jm058173s

Reference yield:

: 5111-65-9
2-Bromo-6-methoxynaphthalene

: 550997-74-5
6-(3-chloro-4-hydroxyphenyl)-2-naphthol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec-BuLi / hexane; tetrahydrofuran / -78 °C

1.2: triisopropyl borate / hexane; tetrahydrofuran

1.3: 100 percent / aq. HCl / hexane; tetrahydrofuran / 0.17 h

2.1: 30 percent / aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

3.1: 98 percent / C₆H₅N*HCl / 2 h / 190 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₆H₅N*HCl; sec.-butyllithium; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; 2.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 156641-98-4
(6-methoxy-2-naphthalene)boronic acid

: 550997-74-5
6-(3-chloro-4-hydroxyphenyl)-2-naphthol

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

2: 98 percent / C₆H₅N*HCl / 2 h / 190 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₆H₅N*HCl; sodium carbonate; In 1,2-dimethoxyethane; 1: Suzuki coupling;
DOI:10.1021/jm058173s