diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate

Base Information

• Chemical Name: diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate
• CAS No.: 916203-67-3
• Molecular Formula: C₁₂H₁₆Cl₂NO₄P
• Molecular Weight: 340.143
• Mol file: 916203-67-3.mol

Synonyms:diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate

Chemical Property of diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate

There total 2 articles about diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

diethyl (2-chloro-2-oxoethyl)phosphonate (34170-81-5) + 2,6-Dichloroaniline (608-31-1) → diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate (916203-67-3)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1021/jo0613479

Reference yield:

diethylphosphonoacetic acid (3095-95-2) → diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate (916203-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 22 °C

2: 60 percent / pyridine / CH₂Cl₂

With pyridine; oxalyl dichloride; In dichloromethane;

DOI:10.1021/jo0613479

Reference yield: 93.0%

diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate (916203-67-3) + bromo-4 chloro-2 formyl-3 pyridine (128071-84-1) → (2E)-3-(4-bromo-2-chloropyridin-3-yl)-N-(2,6-dichlorophenyl)acrylamide

Guidance literature:

diethyl {2-[(2,6-dichlorophenyl)amino]-2-oxoethyl}phosphonate; With potassium tert-butylate; In tetrahydrofuran; for 1.5h;

bromo-4 chloro-2 formyl-3 pyridine; In tetrahydrofuran; at 22 ℃; for 2.5h;

DOI:10.1021/jo0613479

upstream raw materials:

diethyl (2-chloro-2-oxoethyl)phosphonate

2,6-Dichloroaniline

diethylphosphonoacetic acid