(3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide

Base Information

• Chemical Name: (3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide
• CAS No.: 1190851-58-1
• Molecular Formula: C₂₃H₂₁BrF₄N₂O₃
• Molecular Weight: 529.329

Synonyms:(3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide

Chemical Property of (3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide

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Technology Process of (3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide

There total 1 articles about (3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3Z,4Z)-N1,N6-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide (1190851-48-9) + sodium methylate (124-41-4) → (3Z,4Z)-N1,N6-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide (1190851-58-1)

Guidance literature:

In tetrahydrofuran; methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo9013436

Reference yield: 92.0%

(3Z,4Z)-N1,N6-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide (1190851-58-1) → (Z)-N-benzyl-3-(1-benzyl-4-fluoro-2-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)-4-bromo-2,2-difluoro-3-butenamide (1190851-71-8)

Guidance literature:

With zinc dibromide; In dichloromethane; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo9013436

Reference yield: 65.0%

(3Z,4Z)-N1,N6-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide (1190851-58-1) → (Z)-N-benzyl-3-(1-benzyl-4,4-difluoro-5-oxo-4,5-dihydro-1H-pyrrol-3-yl)-2,2-difluoro-4-methoxybut-3-enamide (1190851-67-2)

Guidance literature:

With copper(l) iodide; caesium carbonate; In toluene; at 80 ℃; for 15h; Inert atmosphere;

DOI:10.1021/jo9013436

upstream raw materials:

(3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide

sodium methylate

Downstream raw materials:

(Z)-N-benzyl-3-(1-benzyl-4,4-difluoro-5-oxo-4,5-dihydro-1H-pyrrol-3-yl)-2,2-difluoro-4-methoxybut-3-enamide

(Z)-N-benzyl-3-(1-benzyl-4-fluoro-2-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)-4-bromo-2,2-difluoro-3-butenamide

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