4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Base Information

Chemical Name:4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
CAS No.:1383854-13-4
Molecular Formula:C₃₀H₂₈F₉N₃O₈S₃
Molecular Weight:825.751
Hs Code.:

4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Synonyms:4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

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Chemical Property of 4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

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Technology Process of 4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

There total 5 articles about 4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 375-72-4
Nonafluorobutanesulfonyl fluoride

: 1383854-12-3
N-(5-cyclopropyl-2-(4-hydroxyphenyl)-3-(1H-imidazol-2-yl)benzofuran-6-yl)-N-(4-(methylsulfonyl)butyl)methanesulfonamide

: 1383854-13-4
4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 20582-85-8
4-(methylthio)-1-butanol

: 1383854-13-4
4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: Oxone / methanol; water / 1.17 h / 0 - 20 °C

2: triethylamine / dichloromethane / 64 h / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 24 h / 50 °C

4: hydrogen / 20% palladium hydroxide-activated charcoal / N,N-dimethyl-formamide / 32 h / 1551.49 Torr

5: potassium carbonate / N,N-dimethyl-formamide / 2 h

With Oxone; hydrogen; potassium carbonate; triethylamine; 20% palladium hydroxide-activated charcoal; In methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 26981-51-1
4-(Methylsulfonyl)-1-butanol

: 1383854-13-4
4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 64 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 24 h / 50 °C

3: hydrogen / 20% palladium hydroxide-activated charcoal / N,N-dimethyl-formamide / 32 h / 1551.49 Torr

4: potassium carbonate / N,N-dimethyl-formamide / 2 h

With hydrogen; potassium carbonate; triethylamine; 20% palladium hydroxide-activated charcoal; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;