N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

Base Information

Chemical Name:N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide
CAS No.:1383854-14-5
Molecular Formula:C₃₂H₃₄N₄O₅S₂
Molecular Weight:618.778
Hs Code.:

Synonyms:N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

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Chemical Property of N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

Chemical Property:

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Technology Process of N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

There total 6 articles about N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1383854-13-4
4-(5-cyclopropyl-3-(1H-imidazol-2-yl)-6-(N-(4-(methylsulfonyl)butyl)methylsulfonamido)benzofuran-2-yl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

: 62-53-3
aniline

: 1383854-14-5
N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

Guidance literature:: With caesium carbonate; palladium diacetate; XPhos; In α,α,α-trifluorotoluene; tert-butyl alcohol; at 130 ℃; for 0.5h; microwave; Inert atmosphere; sealed tube;

Reference yield:

: 20582-85-8
4-(methylthio)-1-butanol

: 1383854-14-5
N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: Oxone / methanol; water / 1.17 h / 0 - 20 °C

2: triethylamine / dichloromethane / 64 h / 0 - 20 °C

3: potassium carbonate / dimethyl sulfoxide / 24 h / 50 °C

4: hydrogen / 20% palladium hydroxide-activated charcoal / N,N-dimethyl-formamide / 32 h / 1551.49 Torr

5: potassium carbonate / N,N-dimethyl-formamide / 2 h

6: caesium carbonate / palladium diacetate; XPhos / α,α,α-trifluorotoluene; tert-butyl alcohol / 0.5 h / 130 °C / microwave; Inert atmosphere; sealed tube

With Oxone; hydrogen; potassium carbonate; caesium carbonate; triethylamine; 20% palladium hydroxide-activated charcoal; palladium diacetate; XPhos; In methanol; dichloromethane; α,α,α-trifluorotoluene; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 26981-51-1
4-(Methylsulfonyl)-1-butanol

: 1383854-14-5
N-[2-(4-anilinophenyl)-5-cyclopropyl-3-(1H-imidazol-2-yl)-1-benzofuran-6-yl]-N-[4-(methylsulfonyl)butyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 64 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 24 h / 50 °C

3: hydrogen / 20% palladium hydroxide-activated charcoal / N,N-dimethyl-formamide / 32 h / 1551.49 Torr

4: potassium carbonate / N,N-dimethyl-formamide / 2 h

5: caesium carbonate / palladium diacetate; XPhos / α,α,α-trifluorotoluene; tert-butyl alcohol / 0.5 h / 130 °C / microwave; Inert atmosphere; sealed tube

With hydrogen; potassium carbonate; caesium carbonate; triethylamine; 20% palladium hydroxide-activated charcoal; palladium diacetate; XPhos; In dichloromethane; α,α,α-trifluorotoluene; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;