5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine

Base Information

• Chemical Name: 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine
• CAS No.: 220456-74-6
• Molecular Formula: C₂₀H₁₃ClN₄
• Molecular Weight: 344.803
• Mol file: 220456-74-6.mol

Synonyms:5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine

Chemical Property of 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine

There total 2 articles about 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5,7-dichloropyrazolo[1,5-a]pyrimidine (57489-77-7) + [[2'-cyano-(1,1'-biphenyl)-4-yl]-methyl]zinc bromide (244127-58-0) → 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine (220456-74-6)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1248/cpb.47.928

Reference yield:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) + 5,7-dichloropyrazolo[1,5-a]pyrimidine (57489-77-7) → 5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine (220456-74-6)

Guidance literature:

With chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc; Yield given; Multistep reaction; 1.) DMF, 0 deg C, 2 h, 2.) room temperature, 1 h;

DOI:10.1021/jo981423a

Reference yield: 90.0%

5-chloro-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine (220456-74-6) + phenylboronic acid (98-80-6) → 5-phenyl-7-<<2'-cyanobiphenyl-4-yl>methyl>pyrazolo<1,5-a>pyrimidine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; for 16h; Heating;

DOI:10.1021/jo981423a

upstream raw materials:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

5,7-dichloropyrazolo[1,5-a]pyrimidine

[[2'-cyano-(1,1'-biphenyl)-4-yl]-methyl]zinc bromide

Downstream raw materials:

4'-<(5-methoxypyrazolo<1,5-a>pyrimidin-7-yl)methyl>biphenyl-2-carbonitrile

4'-<(5-dimethylaminopyrazolo<1,5-a>pyrimidin-7-yl)methyl>biphenyl-2-carbonitrile

4'-<(5-methylthiopyrazolo<1,5-a>pyrimidin-7-yl)methyl>biphenyl-2-carbonitrile