2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

Base Information

Chemical Name:2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid
CAS No.:900174-88-1
Molecular Formula:C₂₈H₃₂FN₃O₆
Molecular Weight:525.577
Hs Code.:

Synonyms:2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

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Chemical Property of 2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

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Technology Process of 2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

There total 1 articles about 2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 298-12-4
Glyoxilic acid

: 166328-16-1
(2-fluoro-5-methylphenyl)boronic acid

: 900174-88-1
2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

Guidance literature:: In N,N-dimethyl-formamide; acetonitrile; at 85 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 900174-71-2
(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride

: 900174-88-1
2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

: 1520082-88-5
C₄₃H₅₂FN₅O₉S

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml400453z

Reference yield:

: 900174-71-2
(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride

: 900174-88-1
2-(1-di-tert-Butoxycarbonylaminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetic acid

: methyl 3-((R)-1-((R)-2-(1-aminoisoquinolin-6-ylamino)-2-(2-fluoro-5-methylphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenylcarbamate trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

2.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/ml400453z