N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

Base Information

Chemical Name:N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide
CAS No.:1266161-57-2
Molecular Formula:C₂₂H₁₈ClN₃O₂
Molecular Weight:391.857
Hs Code.:

Synonyms:N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

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Chemical Property of N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

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Technology Process of N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

There total 5 articles about N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266161-56-1
N-(3,5-dichloro-4-cyanopyridin-2-yl)-N-o-tolylacetamide

: 5720-07-0
4-methoxyphenylboronic acid

: 1266161-57-2
N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

: C₂₂H₁₈ClN₃O₂

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;

Reference yield:

: 42182-27-4
4-cyanopyridin-2-amine

: 1266161-57-2
N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

: C₂₂H₁₈ClN₃O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 55 °C

2.1: sodium nitrite; tetrafluoroboric acid / 1 h / -10 °C

2.2: Cooling with ice

3.1: 20 h / 150 °C

4.1: 20 h / 180 °C / Sealed tube

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; N-chloro-succinimide; tetrafluoroboric acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; 5.1: Suzuki Coupling;

Reference yield:

: 1260654-33-8
2-amino-3,5-dichloroisonicotinonitrile

: 1266161-57-2
N-(3-chloro-4-cyano-5-(4-methoxyphenyl)pyridin-2-yl)-N-o-tolylacetamide

: C₂₂H₁₈ClN₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; tetrafluoroboric acid / 1 h / -10 °C

1.2: Cooling with ice

2.1: 20 h / 150 °C

3.1: 20 h / 180 °C / Sealed tube

4.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / 100 °C / Inert atmosphere; Sealed tube

With potassium phosphate; tetrafluoroboric acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; 4.1: Suzuki Coupling;