gamma-Glutamylvaline

Base Information

• Chemical Name: gamma-Glutamylvaline
• CAS No.: 2746-34-1
• Molecular Formula: C10H18 N2 O5
• Molecular Weight: 246.263
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID801316652
• Nikkaji Number: J2.022.164J
• Wikidata: Q27137212
• Metabolomics Workbench ID: 65198
• Mol file: 2746-34-1.mol

Synonyms:gamma-Glu-Val;gamma-glutamylvaline

Chemical Property of gamma-Glutamylvaline

Chemical Property:

• PSA: 133.21000
• LogP: 0.94450
• Storage Temp.: -15°C
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 246.12157168
• Heavy Atom Count: 17
• Complexity: 303

Purity/Quality:

99%+, ^*data from raw suppliers

H-GAMMA-GLU-VAL-OH 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)O)NC(=O)CCC(C(=O)O)N
• Isomeric SMILES: CC(C)[C@@H](C(=O)O)NC(=O)CC[C@@H](C(=O)O)N

Technology Process of gamma-Glutamylvaline

There total 6 articles about gamma-Glutamylvaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.4%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + L-glutamine (56-85-9,26700-71-0) → γ-L-glutamyl-L-valine (2746-34-1) + L-γ-glutamyl-L-glutamine (10148-81-9)

Guidance literature:

With sodium hydroxide; Escherichia coli K-12 SH642 γ-glutamyltranspeptidase; at 37 ℃; for 3h; pH=10;

DOI:10.1021/jf0347564

Reference yield: 24.0%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + monosodium L-glutamate (142-47-2) → γ-L-glutamyl-L-valine (2746-34-1)

Guidance literature:

With adenosine 5'-triphosphate sodium salt; magnesium chloride; bovine serum albumin; at 30 ℃; for 24h; γ-glutamylcysteine synthetase from Proteus mirabilis, pH 8.5;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + L-glutamine (56-85-9,26700-71-0) → γ-L-glutamyl-L-valine (2746-34-1) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + L-γ-glutamyl-L-glutamine (10148-81-9) + γ-L-glutamyl-L-glutamic acid (1116-22-9)

Guidance literature:

glutaminase from Aspergillus oryzae; at 30 ℃; Yield given; pH=8.5 (tris-HCl buffer);

upstream raw materials:

N-(N-benzyloxycarbonyl-L-γ-glutamyl)-L-valine

L-valine

L-glutamine

monosodium L-glutamate

Refernces

• 1、 Tomita, Kenji,Yano, Toshihiro,Kitagata, Tatsuichiro,Kumagai, Hidehiko,Tochikura, Tatsurokuro. "Formation of γ-Glutamyl Peptides by Glutaminase of Aspergillus oryzae". . p. 1995 - 1996. Retrieved 2007/10/02.