methyl 3-ketocholanate tosylhydrazone

Base Information

• Chemical Name: methyl 3-ketocholanate tosylhydrazone
• CAS No.: 77285-18-8
• Molecular Formula: C₃₂H₄₈N₂O₄S
• Molecular Weight: 556.81
• Mol file: 77285-18-8.mol

Synonyms:methyl 3-ketocholanate tosylhydrazone

Chemical Property of methyl 3-ketocholanate tosylhydrazone

Chemical Property:

Purity/Quality:

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Technology Process of methyl 3-ketocholanate tosylhydrazone

There total 1 articles about methyl 3-ketocholanate tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 3-oxo-5β-cholan-24-oate (1173-32-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → methyl 3-ketocholanate tosylhydrazone (77285-18-8)

Guidance literature:

In acetic acid; for 12h; Ambient temperature;

DOI:10.1055/s-1984-31036

Reference yield:

methyl 3-ketocholanate tosylhydrazone (77285-18-8) → 5β-chol-3-en-24-oic acid (28083-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.09 g / KH / toluene / 3 h / Heating

2: 718 mg / 1N KOH / methanol / 4 h / Heating

With potassium hydroxide; potassium hydride; In methanol; toluene;

DOI:10.1248/cpb.29.137

upstream raw materials:

methyl 3-oxo-5β-cholan-24-oate

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

5β-chol-3-en-24-oic acid