cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis

Base Information

• Chemical Name: cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis
• CAS No.: 135619-32-8
• Molecular Formula: C₂₂H₃₆N₂O₈
• Molecular Weight: 456.536
• Mol file: 135619-32-8.mol

Synonyms:cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis

Chemical Property of cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis

There total 1 articles about cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cis-4-cyclohexene-1,2-diamine hydrochloride (365997-24-6,500571-15-3) + ethyl bromoacetate (105-36-2) → cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis (135619-32-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 24h; Ambient temperature;

DOI:10.1021/jo00018a039

Reference yield: 70.0%

cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis (135619-32-8) → (1α,2α,4β,5β)-diethyl N,N'-(4,5-dihydroxy-1,2-cyclohexanediyl)bis (135619-33-9)

Guidance literature:

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrachloromethane; water; acetone; tert-butyl alcohol; for 24h; Ambient temperature;

DOI:10.1021/jo00018a039

Reference yield:

cis-diethyl N,N'-(4-cyclohexene-1,2-diyl)bis (135619-32-8) → (1α,2α,4β,5β)-4,4'-(4,5-dihydroxy-1,2-cyclohexanediyl)bis(2,6-piperazinedione) (135683-27-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / OsO₄, N-methylmorpholine N-oxide monohydrate / acetone; H₂O; 2-methyl-propan-2-ol; CCl₄ / 24 h / Ambient temperature

2: 100 percent / TsOH / acetone / 1 h / Ambient temperature

3: 36 percent / NaH / dioxane / 24 h / 70 - 75 °C

4: 40 percent / 1.5 N aq. HCl / Ambient temperature

With hydrogenchloride; osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In 1,4-dioxane; tetrachloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1021/jo00018a039

upstream raw materials:

cis-4-cyclohexene-1,2-diamine hydrochloride

ethyl bromoacetate

Downstream raw materials:

(1α,2α,4β,5β)-diethyl N,N'-(4,5-dihydroxy-1,2-cyclohexanediyl)bis

(1α,2α,4β,5β)-4,4'-(4,5-dihydroxy-1,2-cyclohexanediyl)bis(2,6-piperazinedione)