Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester

Base Information

• Chemical Name: Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester
• CAS No.: 152901-78-5
• Molecular Formula: C₂₁H₂₆O₄
• Molecular Weight: 342.435
• Mol file: 152901-78-5.mol

Synonyms:Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester

Chemical Property of Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester

There total 5 articles about Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cesium acetate (3396-11-0) + Methanesulfonic acid (1R,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester (152901-77-4) → Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester (152901-78-5)

Guidance literature:

With 18-crown-6 ether; In benzene;

DOI:10.1016/S0040-4039(00)73859-7

Reference yield:

benzyl bromide (100-39-0) → Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester (152901-78-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH

2: 83 percent / Amberlyst H₁₅

3: 87 percent / pyridine

4: 96 percent / 18-crown-6 / benzene

With pyridine; 18-crown-6 ether; Amberlyst H₁₅; sodium hydride; In benzene;

DOI:10.1016/S0040-4039(00)73859-7

Reference yield:

(2R,3R)-erythro-3-methylbutane-1,2,4-triol 2-THP ether (74243-87-1) → Acetic acid (1S,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester (152901-78-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH

2: 83 percent / Amberlyst H₁₅

3: 87 percent / pyridine

4: 96 percent / 18-crown-6 / benzene

With pyridine; 18-crown-6 ether; Amberlyst H₁₅; sodium hydride; In benzene;

DOI:10.1016/S0040-4039(00)73859-7

upstream raw materials:

cesium acetate

Methanesulfonic acid (1R,2R)-3-benzyloxy-1-benzyloxymethyl-2-methyl-propyl ester

benzyl bromide

(2R,3R)-erythro-3-methylbutane-1,2,4-triol 2-THP ether