Technology Process of N-(3-{(14R)-14-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2,16,16,17,17-penta-methyl-5,15-dioxa-2,12-diaza-16-silaoctadec-1-yl}phenyl)urea
There total 13 articles about N-(3-{(14R)-14-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2,16,16,17,17-penta-methyl-5,15-dioxa-2,12-diaza-16-silaoctadec-1-yl}phenyl)urea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; sodium iodide;
In
dimethyl sulfoxide;
at 85 ℃;
for 38h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydroxide / tetrabutylammomium bromide / water / 5 h / 20 °C
2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C
3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr
4: triethylamine / dichloromethane / 20 °C
5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 72 h / 70 °C
6: hydrazine / ethanol / 20 °C / Heating / reflux
7: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 38 h / 85 °C
With
sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; sodium iodide; hydrazine;
palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide;
In
methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: water; acetic acid / 0.5 h / 0 - 20 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 2070.21 Torr
3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 72 h / 70 °C
4: hydrazine / ethanol / 20 °C / Heating / reflux
5: sodium hydrogencarbonate; sodium iodide / dimethyl sulfoxide / 38 h / 85 °C
With
hydrogen; sodium hydrogencarbonate; sodium iodide; hydrazine;
palladium 10% on activated carbon;
In
methanol; ethanol; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
