2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one

Base Information

• Chemical Name: 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one
• CAS No.: 1453188-51-6
• Molecular Formula: C₂₂H₂₀N₂O
• Molecular Weight: 328.414
• Mol file: 1453188-51-6.mol

Synonyms:2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one

Chemical Property of 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one

There total 4 articles about 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzyl-N-(4-aminophenyl)-3-phenylacrylamide (100411-13-0) → 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one (1453188-51-6) + N1-benzyl-benzene-1,4-diamine (17272-83-2)

Guidance literature:

With trifluorormethanesulfonic acid; In chloroform; at 65 ℃; for 18h;

DOI:10.1016/j.tet.2013.07.075

Reference yield:

benzyl bromide (100-39-0) → 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one (1453188-51-6) + N1-benzyl-benzene-1,4-diamine (17272-83-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / Reflux

2: tin(ll) chloride / ethanol / 3 h / Reflux

3: trifluorormethanesulfonic acid / chloroform / 18 h / 65 °C

With trifluorormethanesulfonic acid; potassium tert-butylate; tin(ll) chloride; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1016/j.tet.2013.07.075

Reference yield:

β-Phenylacrylic acid 4-nitroanilide (134430-90-3,74948-33-7) → 2-(4-aminophenyl)-5-phenyl-1,2,4,5-tetrahydro-2-benzazepin-3-one (1453188-51-6) + N1-benzyl-benzene-1,4-diamine (17272-83-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / Reflux

2: tin(ll) chloride / ethanol / 3 h / Reflux

3: trifluorormethanesulfonic acid / chloroform / 18 h / 65 °C

With trifluorormethanesulfonic acid; potassium tert-butylate; tin(ll) chloride; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1016/j.tet.2013.07.075

upstream raw materials:

benzyl bromide

β-Phenylacrylic acid 4-nitroanilide

N-benzyl-N-(4-nitrophenyl)-3-phenylacrylamide

N-benzyl-N-(4-aminophenyl)-3-phenylacrylamide