3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

Base Information

• Chemical Name: 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester
• CAS No.: 644968-17-2
• Molecular Formula: C₂₄H₃₉NO₅
• Molecular Weight: 421.577

Synonyms:3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

Chemical Property of 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

There total 3 articles about 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyloxypropionitrile (6328-48-9) → 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester (644968-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / CoCl₂*6H₂O / methanol / 2 h / 20 °C

2: 2.95 g / methanol / 6 h / 20 °C

With sodium tetrahydroborate; cobalt(II) chloride; In methanol; 2: Michael addition;

DOI:10.1021/jo035072y

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester (644968-17-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / NaOH / H₂O / 6 h / 20 °C

2: NaBH₄ / CoCl₂*6H₂O / methanol / 2 h / 20 °C

3: 2.95 g / methanol / 6 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; cobalt(II) chloride; In methanol; water; 1: Michael addition / 3: Michael addition;

DOI:10.1021/jo035072y

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) + 3-benzyloxypropylamine (16728-64-6) → 3-[(3-benzyloxy-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester (644968-17-2)

Guidance literature:

In methanol; at 20 ℃; for 6h;

DOI:10.1021/jo035072y

upstream raw materials:

tert-Butyl acrylate

3-benzyloxypropylamine

3-benzyloxypropionitrile

benzyl alcohol

Downstream raw materials:

3-(3-{[3-(3-{[3-(3-{bis-[3-(2-cyano-ethoxy)-propyl]-amino}-propoxy)-propyl]-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-[3-(2-cyano-ethoxy)-propyl]-amino}-propoxy)-propionitrile

3-[[3-(3-{(3-{3-[bis-(2-tert-butoxycarbonyl-ethyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

3-[(3-{3-[(3-benzyloxy-propyl)-(3-{3-[bis-(2-tert-butoxycarbonyl-ethyl)-amino]-propoxy}-propyl)-amino]-propoxy}-propyl)-(2-tert-butoxycarbonyl-ethyl)-amino]-propionic acid tert-butyl ester

3-[[3-(3-{(3-{3-[bis-(3-hydroxy-propyl)-amino]-propoxy}-propyl)-[3-(4-methoxy-phenoxy)-propyl]-amino}-propoxy)-propyl]-(3-hydroxy-propyl)-amino]-propan-1-ol

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