1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
• CAS No.: 28862-12-6
• Molecular Formula: C10H9 N3 O2
• Molecular Weight: 203.2
• Hs Code.: 2933998090
• Mol file: 28862-12-6.mol

Synonyms:1H-1,2,3-Triazole-4-carboxylicacid, 1-benzyl- (8CI)

Chemical Property of 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.651
• Boiling Point: 453.798°C at 760 mmHg
• Flash Point: 228.249°C
• PSA: 68.01000
• Density: 1.343g/cm³
• LogP: 1.02460
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-1H-1,2,3-triazole-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID

There total 17 articles about 1-BENZYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl azide (622-79-7) + Propiolic acid (471-25-0) → 1-benzyl-1H-[1,2,3]triazol-4-carboxylic acid (28862-12-6)

Guidance literature:

With Cu(I)complex of dendrimer of triazole rings with triethylene glycol termini; In water; at 30 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja5061388

Reference yield: 95.0%

C18H16N4O (1016013-16-3) → 1-indoline (496-15-1) + 1-benzyl-1H-[1,2,3]triazol-4-carboxylic acid (28862-12-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 80 ℃; for 4h; Temperature; Time;

DOI:10.1039/c3sc51211h

Reference yield: 92.0%

propynoic acid methyl ester (922-67-8) + benzyl azide (622-79-7) + Propiolic acid (471-25-0) → 1-benzyl-1H-[1,2,3]triazol-4-carboxylic acid (28862-12-6)

Guidance literature:

propynoic acid methyl ester; Propiolic acid; With 2-nitrophenylboronic acid; In 1,2-dichloro-ethane; at 25 ℃; for 0.166667h; Inert atmosphere;

benzyl azide; In 1,2-dichloro-ethane; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.200903484

upstream raw materials:

benzyl azide

Propiolic acid

1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

benzyl bromide

Downstream raw materials:

bis(1-benzyl-1H-[1,2,3]triazol-4-carboxylate)platinum(II)

1-benzyl-N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1H-1,2,3-triazole-4-carboxamide

Refernces

• 1、 Xiao, Dawei,Do, Loi H.. "Triazolecarboxamidate Donors as Supporting Ligands for Nickel Olefin Polymerization Catalysts". . p. 254 - 260. Retrieved 2018.
• 2、 Pazoki, Farzane,Salamatmanesh, Arefe,Bagheri, Sepideh,Heydari, Akbar. "Synthesis and Characterization of Copper(I)‐Cysteine Complex Supported on Magnetic Layered Double Hydroxide as an Efficient and Recyclable Catalyst System for Click Chemistry Using Choline Azide as Reagent and Reaction Medium". . p. 1186 - 1195. Retrieved 2019/11/16.
• 3、 Alvala, Mallika,Babu, Bathini Nagendra,Devi, Ganthala Parimala,Godugu, Chandraiah,Manasa, Kesari Lakshmi,Nagesh, Narayana,Sigalapalli, Dilep Kumar,Thatikonda, Sowjanya,Vuppaladadium, Sowmya. "Design and synthesis of substituted (1-(benzyl)-1: H -1,2,3-triazol-4-yl)(piperazin-1-yl)methanone conjugates: Study on their apoptosis inducing ability and tubulin polymerization inhibition". supporting information. p. 1295 - 1302. Retrieved 2020/12/01.