{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

Base Information

Chemical Name:{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester
CAS No.:192774-13-3
Molecular Formula:C₄₅H₅₆N₄O₅S
Molecular Weight:765.029
Hs Code.:

{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

Synonyms:{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

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Chemical Property of {2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

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Technology Process of {2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

There total 13 articles about {2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-89-7
diethylamine

: 192774-12-2
2-[3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

: 192774-13-3
{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 192774-13-3
{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: BOP; Et₃N / CH₂Cl₂

2: H₂ / Pd(OH)2/C / ethanol

3: pyridine

4: LiAlH₄ / tetrahydrofuran / 0 °C

5: Me₂SO₄ / CDCl₃ / -10 - -5 °C

6: NaBH₄ / methanol / -5 °C

7: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

8: aq. KOH / methanol / Heating

9: PyBOP; Et₃N / CH₂Cl₂

With pyridine; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dimethyl sulfate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 192774-14-4
4-(4-nitrophenyl)butyric acid, N-methoxy-N-methylamide

: 192774-13-3
{2-[5-(1-diethylcarbamoyl-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-indol-3-yl]ethyl}-[4-(4-methanesulfonylaminophenyl)butyl]carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd(OH)2/C / ethanol

2: pyridine

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: Me₂SO₄ / CDCl₃ / -10 - -5 °C

5: NaBH₄ / methanol / -5 °C

6: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

7: aq. KOH / methanol / Heating

8: PyBOP; Et₃N / CH₂Cl₂

With pyridine; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; dimethyl sulfate; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8