(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

Base Information

Chemical Name:(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane
CAS No.:1374763-99-1
Molecular Formula:C₂₆H₄₄O₃
Molecular Weight:404.634
Hs Code.:

Synonyms:(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

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Chemical Property of (4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

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Technology Process of (4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

There total 7 articles about (4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 75-29-6
isopropyl chloride

: 1374763-98-0
C₂₃H₃₇IO₃

: 1374763-99-1
(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

Guidance literature:: isopropyl chloride; With magnesium; In tetrahydrofuran; for 0.5h; Inert atmosphere; Reflux;

C₂₃H₃₇IO₃; With copper(l) cyanide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0031-1290155

Reference yield:

: 1374763-96-8
(2S,4R,5R,6R)-5-(benzyloxy)-N-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-N,2,4-trimethyl-6-[(4R,5R)-2,2,5-trimethyl-1,3-dioxan-4-yl]heptanamide

: 1374763-99-1
(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-ammonia complex; n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole; iodine; triphenylphosphine / toluene / 3 h / 0 - 20 °C / Inert atmosphere

3.1: magnesium / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

3.2: 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; borane-ammonia complex; iodine; magnesium; diisopropylamine; triphenylphosphine; In tetrahydrofuran; hexane; toluene;
DOI:10.1055/s-0031-1290155

Reference yield:

: 1374763-97-9
(2S,4R,5R,6R)-5-(benzyloxy)-2,4-dimethyl-6-[(4R,5R)-2,2,5-trimethyl-1,3-dioxan-4-yl]heptan-1-ol

: 1374763-99-1
(4R,5R)-4-[(2R,3R,4R,6R)-3-(benzyloxy)-4,6,8-trimethylnonan-2-yl]-2,2,5-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole; iodine; triphenylphosphine / toluene / 3 h / 0 - 20 °C / Inert atmosphere

2.1: magnesium / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

2.2: 1 h / 20 °C / Inert atmosphere

With 1H-imidazole; iodine; magnesium; triphenylphosphine; In tetrahydrofuran; toluene;
DOI:10.1055/s-0031-1290155