3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

Base Information

Chemical Name:3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid
CAS No.:123282-15-5
Molecular Formula:C₁₈H₁₆N₂O₆S
Molecular Weight:388.401
Hs Code.:

Synonyms:3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

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Chemical Property of 3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

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Technology Process of 3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

There total 3 articles about 3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 123282-06-4
4-Benzyl-6-chloro-7-nitro-4H-benzo[1,4]oxazin-3-one

: 107-96-0
3-mercaptopropionic acid

: 123282-15-5
3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 4h;

Reference yield:

: 7652-29-1
6-chloro-2H-1,4-benzoxazin-3(4H)-one

: 123282-15-5
3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / KNO₃, conc. H₂SO₄ / 1 h / 0 - 5 °C

2: 84 percent / K₂CO₃, 18-crown-6 / acetonitrile / 1 h / Heating

3: 79 percent / K₂CO₃ / dimethylformamide / 4 h / 70 - 80 °C

With 18-crown-6 ether; sulfuric acid; potassium carbonate; potassium nitrate; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 116862-22-7
6-chloro-7-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one

: 123282-15-5
3-(4-Benzyl-7-nitro-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylsulfanyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃, 18-crown-6 / acetonitrile / 1 h / Heating

2: 79 percent / K₂CO₃ / dimethylformamide / 4 h / 70 - 80 °C

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;