1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

Base Information

Chemical Name:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride
CAS No.:913571-42-3
Molecular Formula:C₁₉H₁₆Cl₂N₂O₂
Molecular Weight:375.254
Hs Code.:

Synonyms:1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

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Chemical Property of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

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Technology Process of 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

There total 4 articles about 1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 851204-79-0
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxylic acid

: 913571-42-3
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2008.05.118

Reference yield:

: 851205-62-4
1-(5-chloro-2-hydroxybenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

: 913571-42-3
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 18 h / Heating / reflux

2: sodium hydroxide; ethanol; water / 0.5 h / Heating / reflux

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.75 - 1.5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; ethanol; water; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetone;

Reference yield:

: 100-39-0
benzyl bromide

: 913571-42-3
1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 18 h / Heating / reflux

2: sodium hydroxide; ethanol; water / 0.5 h / Heating / reflux

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.75 - 1.5 h / 20 °C

With sodium hydroxide; oxalyl dichloride; ethanol; water; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; acetone;