3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

Base Information

Chemical Name:3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate
CAS No.:139392-26-0
Molecular Formula:C₂₀H₂₆N₂O₅S
Molecular Weight:406.503
Hs Code.:

Synonyms:3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

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Chemical Property of 3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

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Technology Process of 3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

There total 16 articles about 3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 124-63-0
methanesulfonyl chloride

: 139392-25-9
3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propanol

: 139392-26-0
3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 1.83333h; Ambient temperature;
DOI:10.3891/acta.chem.scand.46-0060

Reference yield:

: 100-44-7
benzyl chloride

: 139392-26-0
3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

Guidance literature:: Multi-step reaction with 8 steps

1: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

2: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

3: 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

4: NaN₃ / tetrahydrofuran; dimethylformamide / 2 h

5: OsO₄, NaIO₄ / tetrahydrofuran; H₂O

6: NaBH₄ / methanol / 0.75 h / 0 °C

7: 163 mg / 2.5 h / Ambient temperature

8: 93 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.83 h / Ambient temperature

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.46-0060

Reference yield:

: 139392-31-7
5-But-3-enyl-4-hydroxymethyl-2-methyl-pyridin-3-ol

: 139392-26-0
3-<4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl>propyl methanesylfonate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.37 g / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.5 h

2: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

3: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

4: 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

5: NaN₃ / tetrahydrofuran; dimethylformamide / 2 h

6: OsO₄, NaIO₄ / tetrahydrofuran; H₂O

7: NaBH₄ / methanol / 0.75 h / 0 °C

8: 163 mg / 2.5 h / Ambient temperature

9: 93 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.83 h / Ambient temperature

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.46-0060