1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

Base Information

Chemical Name:1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea
CAS No.:1071964-47-0
Molecular Formula:C₂₉H₃₄FN₅O₄
Molecular Weight:535.618
Hs Code.:

Synonyms:1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

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Chemical Property of 1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

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Technology Process of 1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

There total 2 articles about 1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 778611-16-8
3-(tert-butyl)-1-(4-fluorophenyl)-1H-pyrazol-5-amine

: 1071964-93-6
C₁₅H₂₀N₂O₃

: 1071964-47-0
1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

Guidance literature:: With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 25 ℃; for 3h;
DOI:10.3390/molecules19022004

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1071964-47-0
1-(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 48 h / Reflux

2: triethylamine; bis(trichloromethyl) carbonate / dichloromethane / 3 h / 25 °C

With hydrogenchloride; bis(trichloromethyl) carbonate; triethylamine; In ethanol; dichloromethane;
DOI:10.3390/molecules19022004