N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Base Information

• Chemical Name: N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine
• CAS No.: 1001014-73-8
• Molecular Formula: C₂₃H₁₉N₇S
• Molecular Weight: 425.517

Synonyms:N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Chemical Property of N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

Chemical Property:

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Technology Process of N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine

There total 8 articles about N₂-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine (1001014-72-7) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-73-8)

Guidance literature:

With hydrogen; palladium over charcoal; In methanol; for 7h; under 2327.23 Torr;

Reference yield:

1-(thiazol-5-yl) ethan-1-one (91516-28-8) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridinium hydrobromide perbromide; hydrogen bromide; acetic acid / 15 h / 20 °C

2.1: potassium hydrogencarbonate / tert-butyl alcohol / 17 h / 50 °C

2.2: 0.33 h / 90 °C

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / 150 °C

4.1: hydrogen / palladium over charcoal / methanol / 7 h / 2327.23 Torr

With pyridinium hydrobromide perbromide; hydrogen bromide; hydrogen; potassium hydrogencarbonate; caesium carbonate; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium over charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; tert-butyl alcohol;

Reference yield:

5-Amino-2-methylpyridine (80287-53-2,3430-14-6) → N2-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)pyridine-2,3-diamine (1001014-73-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 18 h / 0 - 20 °C

2.1: trichlorophosphate / 18 h / 105 °C

2.2: 1.75 h / 0 - 20 °C

3.1: potassium hydrogencarbonate / tert-butyl alcohol / 17 h / 50 °C

3.2: 0.33 h / 90 °C

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2.5 h / 150 °C

5.1: hydrogen / palladium over charcoal / methanol / 7 h / 2327.23 Torr

With hydrogen; potassium hydrogencarbonate; caesium carbonate; triethylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium over charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; tert-butyl alcohol;

upstream raw materials:

N-(4-(1-(6-methylpyridin-3-yl)-4-(thiazol-5-yl)-1H-imidazol-2-yl)phenyl)-3-nitropyridin-2-amine

5-Amino-2-methylpyridine

1-(thiazol-5-yl) ethan-1-one

2-bromo-1-(thiazol-5-yl)ethanone hydrobromide

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