3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

Base Information

Chemical Name:3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide
CAS No.:1255148-94-7
Molecular Formula:C₂₆H₂₁FN₄O₆
Molecular Weight:504.474
Hs Code.:

Synonyms:3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

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Chemical Property of 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

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Technology Process of 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

There total 4 articles about 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255149-06-4
C₂₈H₂₅FN₄O₇

: 1255148-94-7
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 20 ℃; for 18h;

Reference yield:

: 616-82-0
3-nitro-4-hydroxybenzoic acid

: 1255148-94-7
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 2 h / 20 °C / Cooling

2: sodium hydroxide; water / methanol / 2 h / 20 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

4: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 1255149-57-5
4-methoxymethoxy-3-nitro benzoic acid

: 1255148-94-7
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

2: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;