3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

Base Information

Chemical Name:3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide
CAS No.:1255149-05-3
Molecular Formula:C₂₇H₂₁FN₄O₄
Molecular Weight:484.487
Hs Code.:

Synonyms:3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

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Chemical Property of 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

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Technology Process of 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

There total 3 articles about 3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255148-94-7
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide

: 70829-28-6
3-cyano-4-hydroxybenzoic acid

: 1255149-05-3
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

Guidance literature:: 3-cyano-4-hydroxybenzoic acid; With thionyl chloride; In ethyl acetate; for 2h; Reflux;

3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid-2-(4-hydroxy-3-nitrobenzoyl)hydrazide; In tetrahydrofuran; at 20 ℃; Cooling;

Reference yield:

: 25978-74-9
3-Cyano-4-methoxy-benzoic acid methyl ester

: 1255149-05-3
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine hydrochloride / 1 h / 180 °C

2.1: thionyl chloride / ethyl acetate / 2 h / Reflux

2.2: 20 °C / Cooling

With thionyl chloride; pyridine hydrochloride; In ethyl acetate;

Reference yield:

: 1255149-63-3
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furancarboxylic acid hydrazide

: 1255149-05-3
3-(4-{[(1S)-1-(4-fluorophenyl)ethyl]amino}phenyl)-2-furan carboxylic acid-2-(3-cyano-4-hydroxybenzoyl)hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: hydrogenchloride / isopropyl alcohol; 1,4-dioxane / 18 h / 20 °C

3.1: thionyl chloride / ethyl acetate / 2 h / Reflux

3.2: 20 °C / Cooling

With hydrogenchloride; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;