tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate
CAS No.:1426235-01-9
Molecular Formula:C₃₁H₄₀N₂O₆
Molecular Weight:536.668
Hs Code.:

Synonyms:tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

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Chemical Property of tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

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Purity/Quality:: 99%+ ^*data from raw suppliers

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Technology Process of tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

There total 18 articles about tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 494224-44-1
[3-(4-tert-butoxycarbonylaminophenyl)-2-oxopropyl]phosphonic acid dimethyl ester

: tert-butyl (4S,5R)-4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

: 1426235-01-9
tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; lithium bromide; In toluene; acetonitrile; at -10 - 20 ℃; Reagent/catalyst;
DOI:10.1021/ol400252p

Reference yield:

: 494224-44-1
[3-(4-tert-butoxycarbonylaminophenyl)-2-oxopropyl]phosphonic acid dimethyl ester

: tert-butyl (4S,5R)-4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

: C₄₈H₆₃N₃O₁₀

: 1426235-01-9
tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; lithium bromide; In toluene; acetonitrile; at -10 - 5 ℃; Reagent/catalyst;
DOI:10.1021/ol400252p

Reference yield:

: 46032-98-8
(1R,2R)-2-amino-1-phenylpropane-1,3-diol

: 1426235-01-9
tert-butyl (4R,5R)-4-((E)-4-(4-((tert-butoxycarbonyl)-amino)phenyl)-3-oxobut-1-en-1-yl)-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 50 °C

1.2: 50 °C

2.1: potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / toluene; water; acetonitrile / 2.5 h / 0 - 5 °C

3.1: lithium bromide; N-ethyl-N,N-diisopropylamine / toluene; acetonitrile / -10 - 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; potassium bromide; lithium bromide; In dichloromethane; water; toluene; acetonitrile; 3.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/ol400252p