methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate

Base Information

• Chemical Name: methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate
• CAS No.: 147744-97-6
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 147744-97-6.mol

Synonyms:methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate

Chemical Property of methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate

There total 6 articles about methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

threo-methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate (439612-08-5) → methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate (147744-97-6)

Guidance literature:

threo-methyl 2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-phenylpropanoate; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 2.16667h;

With N-ethyl-N,N-diisopropylamine; at 0 ℃; for 1h;

Reference yield: 95.0%

di-tert-butyl dicarbonate (24424-99-5) + α-Phenylacyl amino acid methyl ester hydrochloride (38061-23-3,81202-39-3) → methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate (147744-97-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1134/S1070363221120252

Reference yield: 84.0%

methyl 2-(N-(tert-butoxycarbonyl)benzamido)acetate → methyl 2-((tert-butoxycarbonyl)amino)-3-oxo-3-phenylpropanoate (147744-97-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

DOI:10.1021/ol102323k

upstream raw materials:

di-tert-butyl dicarbonate

α-Phenylacyl amino acid methyl ester hydrochloride

N-(tert-butoxycarbonyl)glycine methyl ester

benzoyl chloride

Downstream raw materials:

2-Amino-3-oxo-3-phenylpropionic acid methylester

methyl 2-acetamido-3-oxo-3-phenylpropanoate

(E)-(R)-2-Acetylamino-2-benzoyl-5-phenyl-pent-4-enoic acid methyl ester

erythro-N-(tert-butoxycarbonyl)-β-hydroxy-L-phenylalanine methyl ester