Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

Base Information

Chemical Name:Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester
CAS No.:186448-76-0
Molecular Formula:C₃₇H₆₆O₇S₃Si
Molecular Weight:747.21
Hs Code.:

Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

Synonyms:Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

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Chemical Property of Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

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Technology Process of Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

There total 10 articles about Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 124-63-0
methanesulfonyl chloride

: 186448-75-9
(R)-2-{2-[(2S,3R)-2-(4-Methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propan-1-ol

: 186448-76-0
Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

Guidance literature:: With triethylamine;
DOI:10.1021/ja963066w

Reference yield:

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

: 186448-76-0
Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi, 2.) BF₃*Et₂O, 3.) Na₂HPO₄, 4.) Na(Hg)

2: 92 percent / Et₃N

3: 87 percent / NaH / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

4: 78 percent / LiI, BF₃*OEt₂ / diethyl ether / -78 °C

5: 84 percent / BF₃*Et₂O / CH₂Cl₂ / -78 °C

6: 1.) t-BuLi / 1.) THF, HMPA, -78 deg C

7: 76 percent / NaH, HMPA

8: 81 percent / Et₃N

With N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; boron trifluoride diethyl etherate; tert.-butyl lithium; sodium hydride; triethylamine; lithium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane;
DOI:10.1021/ja963066w

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 186448-76-0
Methanesulfonic acid (R)-2-{2-[(2S,3R)-2-(4-methoxy-benzyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butyl]-[1,3]dithian-2-yl}-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / BF₃*Et₂O / CH₂Cl₂ / -78 °C

2: 1.) t-BuLi / 1.) THF, HMPA, -78 deg C

3: 76 percent / NaH, HMPA

4: 81 percent / Et₃N

With N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; tert.-butyl lithium; sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/ja963066w