Technology Process of ethyl (4E)-6-(2-O-tert-butyldimethylsilyloxy-6-methoxyphenyl)-2,3,4-trimethylhex-4-enoate
There total 4 articles about ethyl (4E)-6-(2-O-tert-butyldimethylsilyloxy-6-methoxyphenyl)-2,3,4-trimethylhex-4-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 66 percent / tetrahydrofuran / -10 °C
2: 85 percent / propionic acid / xylene / 145 °C
With
propionic acid;
In
tetrahydrofuran; xylene;
2: Claisen-Johnson ortho ester rearrangement;
DOI:10.1016/j.bmc.2005.07.013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / KMnO4; H5IO6 / propan-2-ol; H2O
2: 66 percent / tetrahydrofuran / -10 °C
3: 85 percent / propionic acid / xylene / 145 °C
With
potassium permanganate; propionic acid; periodic acid;
In
tetrahydrofuran; water; isopropyl alcohol; xylene;
3: Claisen-Johnson ortho ester rearrangement;
DOI:10.1016/j.bmc.2005.07.013
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 10 h / 20 °C
1.2: CuI / 1 h / 20 °C
1.3: 96 percent / 2 h / Heating
2.1: 83 percent / imidazole / dimethylformamide / 8 h / 20 °C
3.1: 68 percent / KMnO4; H5IO6 / propan-2-ol; H2O
4.1: 66 percent / tetrahydrofuran / -10 °C
5.1: 85 percent / propionic acid / xylene / 145 °C
With
1H-imidazole; potassium permanganate; n-butyllithium; propionic acid; periodic acid;
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; xylene;
5.1: Claisen-Johnson ortho ester rearrangement;
DOI:10.1016/j.bmc.2005.07.013
