N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

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Chemical Name:N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide
CAS No.:607390-57-8
Molecular Formula:C₄₀H₄₂F₆N₄O₉S
Molecular Weight:868.851
Hs Code.:

<i>N</i>-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

Synonyms:N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

There total 5 articles about N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 383-63-1
ethyl trifluoroacetate,

: 1-{(2R,3R,4R,5R)-3-[4-Amino-2-(2-amino-ethyl)-butylsulfanyl]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

: 607390-57-8
N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 16h;
DOI:10.1021/ja035186r

Reference yield:

: 83088-00-0
2'-deoxy-2'-(4-methoxyphenylmethanethio)uridine

: 607390-57-8
N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: TFA; phenol / 2 h / Heating

2: DIEA / acetonitrile / 16 h / 20 °C

3: pyridine / 2 h / 20 °C

4: hydrazine / methanol / 3 h / Heating

5: Et₃N / methanol / 16 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; hydrazine; phenol; In methanol; acetonitrile;
DOI:10.1021/ja035186r

Reference yield:

: 31281-28-4
2'-mercapto-2'-deoxyuridine

: 607390-57-8
N-[3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-tetrahydro-furan-3-ylsulfanylmethyl]-5-(2,2,2-trifluoro-acetylamino)-pentyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: DIEA / acetonitrile / 16 h / 20 °C

2: pyridine / 2 h / 20 °C

3: hydrazine / methanol / 3 h / Heating

4: Et₃N / methanol / 16 h / 20 °C

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; In methanol; acetonitrile;
DOI:10.1021/ja035186r