2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide

Base Information

• Chemical Name: 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide
• CAS No.: 131356-19-9
• Molecular Formula: C₁₀H₁₆N₂O₄S₂
• Molecular Weight: 292.38
• Mol file: 131356-19-9.mol

Synonyms:2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide

Chemical Property of 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide

There total 4 articles about 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide (132351-54-3) → 4-(dimethylamino)-2,6-bis(methylsulfonyl)aniline + 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-19-9)

Guidance literature:

In acetonitrile; for 3h; Irradiation; Inert atmosphere;

DOI:10.1002/chem.201603522

Reference yield: 9.6%

p-dimethylaminonitrosobenzene (138-89-6) → N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide (132351-54-3) + 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-19-9) + 3-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-20-2) + 3-methyl-2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-21-3) + N,N-Dimethyl-4-nitroaniline (100-23-2)

Guidance literature:

With dihydrogen peroxide; iron(II) sulfate; In dimethyl sulfoxide; for 0.75h; Product distribution; Mechanism; Ambient temperature;

DOI:10.1039/P29900001929

Reference yield:

4-amino-N,N-dimethylaniline (99-98-9) → 4-(dimethylamino)-2,6-bis(methylsulfonyl)aniline + 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium hydroxide / water / 0.5 h

3: acetonitrile / 3 h / Irradiation; Inert atmosphere

With pyridine; sodium hydroxide; In dichloromethane; water; acetonitrile;

DOI:10.1002/chem.201603522

upstream raw materials:

p-dimethylaminonitrosobenzene

N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide

4-amino-N,N-dimethylaniline

N-[p-(dimethylamino)phenyl]methanesulfonamide