N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide

Base Information

• Chemical Name: N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide
• CAS No.: 132351-54-3
• Molecular Formula: C₁₀H₁₆N₂O₄S₂
• Molecular Weight: 292.38
• Mol file: 132351-54-3.mol

Synonyms:N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide

Chemical Property of N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide

There total 3 articles about N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-[p-(dimethylamino)phenyl]methanesulfonamide (63084-78-6) + methanesulfonyl chloride (124-63-0) → N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide (132351-54-3)

Guidance literature:

With sodium hydroxide; In water; for 0.5h;

DOI:10.1002/chem.201603522

Reference yield: 9.6%

p-dimethylaminonitrosobenzene (138-89-6) → N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide (132351-54-3) + 2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-19-9) + 3-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-20-2) + 3-methyl-2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide (131356-21-3) + N,N-Dimethyl-4-nitroaniline (100-23-2)

Guidance literature:

With dihydrogen peroxide; iron(II) sulfate; In dimethyl sulfoxide; for 0.75h; Product distribution; Mechanism; Ambient temperature;

DOI:10.1039/P29900001929

Reference yield:

4-amino-N,N-dimethylaniline (99-98-9) → N-[4-(dimethylamino)phenyl]-N-(methylsulfonyl)methanesulfonamide (132351-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium hydroxide / water / 0.5 h

With pyridine; sodium hydroxide; In dichloromethane; water;

DOI:10.1002/chem.201603522

upstream raw materials:

p-dimethylaminonitrosobenzene

4-amino-N,N-dimethylaniline

N-[p-(dimethylamino)phenyl]methanesulfonamide

methanesulfonyl chloride

Downstream raw materials:

2-methanesulphonyl-4-(N,N-dimethylamino)-N-methanesulphonanilide