N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide
• CAS No.: 1333467-17-6
• Molecular Formula: C₂₃H₃₁NO₃S
• Molecular Weight: 401.57

Synonyms:N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide

Chemical Property of N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide

There total 1 articles about N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-methylcyclobutane-1-carbaldehyde (65338-30-9) + 4-(p-toluenesulfonyl)-4-azaundec-1,6-diyne (1236313-43-1) → N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide (1333467-17-6)

Guidance literature:

4-(p-toluenesulfonyl)-4-azaundec-1,6-diyne; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

1-methylcyclobutane-1-carbaldehyde; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;

DOI:10.1002/chem.201101441

Reference yield:

N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide (1333467-17-6) + benzenesulfenyl chloride (931-59-9) → C29H35NO3S2

Guidance literature:

With triethylamine; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1002/chem.201101441

Reference yield:

N-(2-heptynyl)-N-{4-hydroxy-4-(1-methylcyclobutyl)-2-butynyl}-4-methylbenzenesulfonamide (1333467-17-6) → N-(2-heptynyl)-N-{4-(1-methylcyclobutyl)-2-phenylsulfonyl-2,3-butadienyl}-4-methylbenzenesulfonamide (1333467-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -78 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201101441

upstream raw materials:

1-methylcyclobutane-1-carbaldehyde

4-(p-toluenesulfonyl)-4-azaundec-1,6-diyne

Downstream raw materials:

N-(2-heptynyl)-N-{4-(1-methylcyclobutyl)-2-phenylsulfonyl-2,3-butadienyl}-4-methylbenzenesulfonamide

7-butyl-3-methyl-N-(4-methylbenzenesulfonyl)-12-phenylsulfonyl-10-azabicyclo[6.4.0]dodeca-1⁽¹²⁾,2,7-triene

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