4-phenyl-1-(p-chlorophenyl)-2-butanone

Base Information

• Chemical Name: 4-phenyl-1-(p-chlorophenyl)-2-butanone
• CAS No.: 37562-71-3
• Molecular Formula: C₁₆H₁₅ClO
• Molecular Weight: 258.748
• Mol file: 37562-71-3.mol

Synonyms:4-phenyl-1-(p-chlorophenyl)-2-butanone

Chemical Property of 4-phenyl-1-(p-chlorophenyl)-2-butanone

Chemical Property:

Purity/Quality:

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Technology Process of 4-phenyl-1-(p-chlorophenyl)-2-butanone

There total 13 articles about 4-phenyl-1-(p-chlorophenyl)-2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

diethyl 4-(4-chlorobenzyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate + 1-(1H-imidazol-1-yl)-3-phenylpropan-1-one (55628-83-6) → 4-phenyl-1-(p-chlorophenyl)-2-butanone (37562-71-3)

Guidance literature:

With 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; caesium carbonate; In acetonitrile; at 20 ℃; Inert atmosphere; Irradiation;

DOI:10.1002/anie.202105354

Reference yield: 3.3%

4-phenyl-1-(p-chlorophenyl)-1-butanone (126314-18-9) → 4-phenyl-1-(p-chlorophenyl)-2-butanone (37562-71-3) + 4-phenyl-1-(p-chlorophenyl)-4-butanone (126314-19-0)

Guidance literature:

With morpholine; sulfur; for 8h; Heating;

Reference yield:

3-Phenylpropionic acid (501-52-0) → 4-phenyl-1-(p-chlorophenyl)-2-butanone (37562-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate / acetonitrile / 20 °C / Inert atmosphere; Irradiation

With 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; caesium carbonate; In dichloromethane; acetonitrile;

DOI:10.1002/anie.202105354

upstream raw materials:

(E)-1-(4-chlorophenyl)-4-phenylbut-3- en-2-one

4-phenyl-1-(p-chlorophenyl)-1-butanone

1-(4-Chloro-phenyl)-4-phenyl-butan-2-ol

1-Bromo-3-phenylpropane