126314-18-9

Usage

Class

Benzodiazepine (psychoactive substances)

Derivatives

Clonazepam and alprazolam (FDA-approved drugs)

Properties

Sedative, hypnotic, and anxiolytic

Availability

Commonly sold on the internet as a research chemical

Recreational use

Often used for recreational purposes

Medical approval

Not approved for medical use

Safety and efficacy

Not established

Health risks

Significant health risks and potentially harmful side effects associated with abuse

Upstream product

• 7484-37-9 (3-phenylpropyl)triphenylphosphonium bromide 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 100-42-5 styrene 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 1073-67-2 4-vinylbenzyl chloride 
• 84379-71-5 1,3-dioxoisoindolin-2-yl 3-phenylpropanoate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 122-01-0 4-chloro-benzoyl chloride 
• 126314-17-8 1-(4-chlorophenyl)-4-phenylbutan-1-ol 

Downstream Products

• 107487-79-6 trans-1-(4-Chlorophenyl)-4-phenylbut-2-ene-1,4-dione 
• 37562-71-3 4-phenyl-1-(p-chlorophenyl)-2-butanone 
• 126314-19-0 4-phenyl-1-(p-chlorophenyl)-4-butanone 

Relevant academic research and scientific papers

Metal-free visible light photoredox enables generation of carbyne equivalents via phosphonium ylide C-H activation

Carbyne, an interesting synthetic intermediate, has recently been generated from hypervalent iodine precursors via photoredox catalysis. Given the underexplored chemistry of carbyne, due to the paucity of carbyne sources, we are intrigued to discover a new source for this reactive species from classical reagents-phosphonium ylides. Our novel strategy employing phosphonium ylides in an olefin hydrocarbonation reaction features a facile approach for constructing carbon-carbon bonds through metal-free and benign reaction conditions. Moreover, the hydrocarbonation products were delivered in a highly regioselective manner.

Switchable Decarboxylative Heck-Type Reaction and Oxo-alkylation of Styrenes with N-Hydroxyphthalimide Esters under Photocatalysis

The switchable visible-light-mediated decarboxylative Heck-type reaction and oxo-alkylation reaction of N-hydroxyphthalimide esters under photocatalysis were developed. Disubstituted or trisubstituted alkenes were obtained in good yield with high E-select

Direct conversion of N-methoxy-N-methylamides (Weinreb amides) to ketones via a nonclassical Wittig reaction

(Chemical Equation Presented) N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product.

The Willgerodt-Kindler Reactions. 6. Isomerization of the Carbonyl Group in Alkanones and Cycloalkanones

The most unusual feature of the Willgerodt-Kindler Reactions is the facile isomerization of the carbonyl function along a chain of unbranched methylene groups, or around a cycloaliphatic ring containing several connected methylene groups.We have demonstrated that the first step in the Kindler process is the formation of enamines by reaction of the carbonyl function with secondary aliphatic amines, followed by reaction of the enamine with certain sulfur-amine catalysts to form reactive heterocyclic sulfur intermediates that facilitate the elimination-readdition of the amines reversibly along the chain.It was shown that compounds of the type R2N-S-S-NR2 are effective catalysts but not compounds of the type R2N-S-NR2.Some cyclohexanone derivatives undergo aromatization, with anomalous results in certain cases.