N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine

Base Information

• Chemical Name: N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine
• CAS No.: 1093660-19-5
• Molecular Formula: C₆₄H₅₅N₇O₈
• Molecular Weight: 1050.18

Synonyms:N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine

Chemical Property of N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine

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Technology Process of N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine

There total 1 articles about N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[1-(4,4'-dimethoxytrityl)-1H-4-imidazolyl]ethyne (1093660-18-4) + N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide (129451-79-2) → N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine (1093660-19-5)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 45 ℃; for 22h; Inert atmosphere;

DOI:10.1002/ejoc.200800381

Reference yield: 53.0%

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethynyl}-2'-deoxyadenosine (1093660-19-5) → N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethyl}-2'-deoxyadenosine (1093660-20-8)

Guidance literature:

With pyridine; platinum(IV) oxide; hydrogen; In dichloromethane; at 20 ℃; for 4h; under 760.051 Torr;

DOI:10.1002/ejoc.200800381

upstream raw materials:

[1-(4,4'-dimethoxytrityl)-1H-4-imidazolyl]ethyne

N-(9-{5-[bis(4-methoxyphenyl)phenylmethoxyphenyl]-4-hydroxytetrahydrofuran-2-yl}-8-bromo-9H-purin-6-yl)benzamide

Downstream raw materials:

N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-8-{2-[N-(4,4'-dimethoxytrityl)-4-imidazolyl]ethyl}-2'-deoxyadenosine

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