(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

Base Information

Chemical Name:(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid
CAS No.:1227087-52-6
Molecular Formula:C₁₆H₁₈F₅NO₃
Molecular Weight:367.316
Hs Code.:

Synonyms:(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

Suppliers and Price of (S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

There total 1 articles about (S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.6%

: 1185762-34-8
2,2-difluoro-2-(4-fluorophenoxy)ethanol

: 1227087-48-0
(S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid hydrochloride

: 1227087-52-6
(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

Guidance literature:: 2,2-difluoro-2-(4-fluorophenoxy)ethanol; With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 20 ℃;

(S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 48h;

With 1-hydroxy-1,1,2-ethanetricarboxylic acid; In water; ethyl acetate;

Reference yield: 36.0%

: 1227087-52-6
(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

: 127946-77-4
1-amino-1-cyclopropanecarbonitrile hydrochloride

: 1227086-94-3
(S)-N-(1-cyanocyclopropyl)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanamide

Guidance literature:: With 4-methyl-morpholine; HATU; In dichloromethane; at 20 ℃;

Reference yield:

: 910544-90-0
(3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide hydrochloride

: 1227087-52-6
(S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid

: 1227087-72-0
(2S)-5-cyclopropyl-N-((3S)-1-(cyclopropylamino)-2-hydroxy-1-oxopentan-3-yl)-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanamide

Guidance literature:: (3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide hydrochloride; (S)-5-cyclopropyl-2-(2,2-difluoro-2-(4-fluorophenoxy)ethylamino)-4,4-difluoropentanoic acid; With 4-methyl-morpholine; HATU; In dichloromethane; at 20 ℃;

With 1-hydroxy-1,1,2-ethanetricarboxylic acid; In dichloromethane; water; ethyl acetate;