N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

Base Information

Chemical Name:N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide
CAS No.:847924-95-2
Molecular Formula:C₂₅H₂₁N₃O₅
Molecular Weight:443.459
Hs Code.:

Synonyms:N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

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Chemical Property of N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

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Technology Process of N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

There total 6 articles about N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 847924-91-8
N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2,3,4-tetrahydropyridin-3-yl}acetamide

: 847924-95-2
N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

Guidance literature:: With manganese(IV) oxide; In toluene; for 8h; Heating;
DOI:10.1002/jhet.5570410602

Reference yield:

: 614-20-0
3-oxo-3-phenylpropionic acid

: 847924-95-2
N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium ethoxide / tetrahydrofuran / 4 h

1.2: 78 percent / N,N'-carbonyldiimidazole / dimethylformamide / 5 h / 20 °C

2.1: 69 percent / ammonium acetate; glacial acetic acid / toluene / Heating

3.1: sodium / ethanol / 0.5 h / 20 °C

3.2: 74 percent / ethyl chloroformate / tetrahydrofuran / 12 h / Heating

4.1: 71 percent / manganese(IV) oxide / toluene / 8 h / Heating

With ammonium acetate; manganese(IV) oxide; sodium; magnesium ethylate; acetic acid; In tetrahydrofuran; ethanol; toluene;
DOI:10.1002/jhet.5570410602

Reference yield:

: 5429-56-1
N-Acetamidoacrylic acid

: 847924-95-2
N-{5-benzoyl-6-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-2-oxo-1,2-dihydropyridin-3-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium / ethanol / 0.5 h / 20 °C

1.2: 74 percent / ethyl chloroformate / tetrahydrofuran / 12 h / Heating

2.1: 71 percent / manganese(IV) oxide / toluene / 8 h / Heating

With manganese(IV) oxide; sodium; In ethanol; toluene;
DOI:10.1002/jhet.5570410602