N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide

Base Information

• Chemical Name: N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide
• CAS No.: 1460301-62-5
• Molecular Formula: C₄₃H₄₂N₄O₅
• Molecular Weight: 694.83

Synonyms:N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide

Chemical Property of N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide

There total 15 articles about N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]exacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-[(10S,12S,16S)-16-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.010'14]hexacosa-1(26),2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide (1460301-55-6) + benzoyl chloride (98-88-4) → N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]exacosa-1(26),2,4,6,22,24-hexaen-16-yl]benzamide (1460301-62-5)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02,7.010,14]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride (1460301-53-4) → N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]exacosa-1(26),2,4,6,22,24-hexaen-16-yl]benzamide (1460301-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 4 h / 0 °C

2: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 4 h / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 2 h / 0 °C

With pyridine; 1-hydroxy-7-aza-benzotriazole; 10 wt% Pd(OH)2 on carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

benzyl N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]hexacosa-1(26),2,4,6,22,24-hexaen-16-yl]carbamate (1460301-54-5) → N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.02'7.01014]exacosa-1(26),2,4,6,22,24-hexaen-16-yl]benzamide (1460301-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 4 h / 20 °C / 760.05 Torr

2: pyridine / dichloromethane / 2 h / 0 °C

With pyridine; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; dichloromethane;

upstream raw materials:

benzyl N-[(10S,12S,16S)-12-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0^2,7.0^10,14]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate hydrochloride

benzyl N-[(10S,12S,16S)-20-methyl-12-{[2-(2-naphthyl)acetyl]amino}-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-16-yl]carbamate

N-[(10S,12S,16S)-16-amino-20-methyl-15,21-dioxo-8-oxa-14,20-diazatetracyclo[20.3.1.0²'⁷.0¹⁰'¹⁴]hexacosa-1⁽²⁶⁾,2,4,6,22,24-hexaen-12-yl]-2-(2-naphthyl)acetamide

benzoyl chloride

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