4-<18F>fluorophenol

Base Information

• Chemical Name: 4-<18F>fluorophenol
• CAS No.: 169518-65-4
• Molecular Formula: C₆H₅FO
• Molecular Weight: 111.105
• Mol file: 169518-65-4.mol

Synonyms:4-<18F>fluorophenol

Chemical Property of 4-<18F>fluorophenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<18F>fluorophenol

There total 15 articles about 4-<18F>fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

→ 4-<18F>fluorophenol (169518-65-4)

Guidance literature:

With K[18F]-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]-hexacosane complex; tetrakis(pyridine)copper(II) bis(trifluoromethanesulfonate); In N,N-dimethyl-formamide; acetonitrile; at 110 ℃; for 0.333333h; Sealed tube;

Reference yield:

para-tert-butylphenol (98-54-4) → 4-<18F>fluorophenol (169518-65-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield:

(p-hydroxyphenyl)boronic acid (71597-85-8) → 4-<18F>fluorophenol (169518-65-4)

Guidance literature:

With pyridine; [¹⁸F]-potassium fluoride; potassium trifluoromethansulfonate; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 0.333333h; Sealed tube;

DOI:10.1021/acs.orglett.5b02875

upstream raw materials:

para-tert-butylphenol

phenol

[⁽¹⁸⁾F]-2-bromo-4-fluorophenol

2-bromo-4-tert-butylphenol