N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Base Information

Chemical Name:N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide
CAS No.:1202705-37-0
Molecular Formula:C₂₀H₂₀F₄N₂O₃
Molecular Weight:412.384
Hs Code.:

Synonyms:N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

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Chemical Property of N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

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Technology Process of N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

There total 1 articles about N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1202705-36-9
methyl 1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxylate

: 108-91-8,157973-60-9
cyclohexylamine

: 1202705-37-0
N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

Guidance literature:: at 100 ℃; for 1h; Microwave irradiation;

Reference yield: 23.0%

: 1202705-37-0
N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide

: 2949-22-6
Glycine ethyl ester isocyanate

: 1202701-40-3
N-[(5-[(cyclohexylamino)carbonyl]-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-2-oxo-1,2-dihydro-3-pyridinyl)carbonyl]glycine

Guidance literature:: N-cyclohexyl-1-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-3-pyridinecarboxamide; Glycine ethyl ester isocyanate; With diethylamine; In chloroform; at 120 ℃; for 1h; Microwave irradiation;

With sodium hydroxide; In ethanol; at 20 ℃; for 0.5h;

With hydrogenchloride; In water;