ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate
CAS No.:1018816-01-7
Molecular Formula:C₂₅H₃₁F₃N₂O₂
Molecular Weight:448.529
Hs Code.:

Synonyms:ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

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Chemical Property of ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

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Technology Process of ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

There total 4 articles about ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356058-18-9
(4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl)methanamine

: 1018815-98-9
ethyl 2-methyl-2-(4-oxo-1-piperidinyl)propanoate

: 1018816-01-7
ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 19h; Inert atmosphere;

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 1018816-01-7
ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 h / Reflux

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 19 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1018816-01-7
ethyl 2-methyl-2-[4-({[4'-(trifluoromethyl)-4-biphenylyl]methyl}amino)-1-piperidinyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 20 h / Reflux

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 19 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; In 1,2-dichloro-ethane; acetonitrile;