356058-18-9Relevant academic research and scientific papers
1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS
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Paragraph 0582, (2014/09/29)
The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
SUBSTITUTED SULFONAMIDE COMPOUNDS
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Page/Page column 55, (2014/04/17)
The invention is concerned with the compounds of formula (I), and salts thereof, wherein X, Y, Z, R1, R2, R3, R3, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
PROCESS FOR PRODUCING BIARYL COMPOUND
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Page/Page column 24, (2008/06/13)
A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.
3-BENZYLTHIO-1,2,4-TRIAZINE-5 (2H)-ONE AS PAF-AH INHIBITORS
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Page/Page column 29, (2010/11/08)
The invention relates to 3-benzylthio-1,2,4-triazine-5 (2H)-one of formula I, methods for the production thereof, and the use thereof for producing medicaments that are used for the treatment and/or prevention of diseases, especially chronic inflammatory diseases, such as diseases of the rheumatic type, and cardiovascular diseases, e.g. dyslipidemia, arteriosclerosis, and coronary heart diseases.
SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES
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Page/Page column 32, (2010/11/08)
The invention relates to substituted 1,2,4-triazin-5(2H)-ones, to a method for the production thereof, and to their use for producing medicaments for treating and/or preventing diseases, particularly chronic inflammatory diseases, for example, rheumatoid
3-CYCLOALKYL-1,2,4-TRIAZIN-5(2H)-ONES
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Page/Page column 25, (2010/11/08)
The invention relates to 3-cycloalkyl-1,2,4-triazin-5(2H)-ones, to a method for the production thereof, and to their use for producing medicaments for treating and/or preventing diseases, particularly chronic inflammatory diseases, for example, rheumatoid
Pyrimidinone compounds
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Page/Page column 20, (2008/06/13)
Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
PYRAZOLECARBOXAMIDE DERIVATIVE, INTERMEDIATE THEREFOR, AND PEST CONTROL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
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Page 25, (2008/06/13)
The present invention provides novel compounds with fungicidal and bactericidal activity as well as insecticidal and miticidal activity, which are useful for controlling hazardous biological organisms and belong to pyrazolecarboxamides represented by the
