2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

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Chemical Name:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone
CAS No.:1225436-44-1
Molecular Formula:C₃₇H₅₃N₃O₅S
Molecular Weight:651.911
Hs Code.:

Synonyms:2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

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Chemical Property of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

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Technology Process of 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

There total 5 articles about 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018827-17-2
2-((1-(4-methoxy-2, 6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy) acetic acid

: 1225436-93-0
9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane

: 1225436-44-1
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

Guidance literature:: 2-((1-(4-methoxy-2, 6-dimethylphenyl-sulfonyl)piperidin-2-yl)methoxy) acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃;

9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane; In dichloromethane; at 0 - 25 ℃;

Reference yield:

: 1021373-55-6
[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-yl]-methanol

: 1225436-44-1
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrabutyl-ammonium chloride / water; toluene / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 25 °C

3.2: 0 - 25 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tetrabutyl-ammonium chloride; In dichloromethane; water; toluene;

Reference yield:

: 874-63-5
3,5-dimethylmethoxybenzene

: 1225436-44-1
2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(9-phenyl-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecan-3-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / dichloromethane / 0 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide / tetrabutyl-ammonium chloride / water; toluene / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 25 °C

5.2: 0 - 25 °C

With chlorosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tetrabutyl-ammonium chloride; In dichloromethane; water; toluene;